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Pemphigoid Antibody Panel
Ordering Recommendation
Use to assess and monitor pemphigoid, pemphigoid variants, and linear IgA disease and to discriminate among the immunobullous diseases with epithelial basement membrane zone antibodies. May be indicated by concurrent Direct Immunofluorescence, Tissue Biopsy (Cutaneous, Mucosal, Epithelial) (0092572). Preferred initial diagnostic serum panel is Basement Membrane Zone Antibody Panel (3001410).
Bullous pemphigoid and other pemphigoid variants, epidermolysis bullosa acquisita (EBA), linear IgA disease, and dermatitis herpetiformis may present with similar clinical findings including blistering, erosions, pruritus, and urticaria, which affect skin and mucous membranes.
To assess for other immunobullous diseases with diagnostic serum epithelial antibodies in addition to pemphigoid, order concurrently with Pemphigus Antibody Panel, IgG (0090650) and Collagen Type VII Antibody, IgG by ELISA (2010905). Alternatively, order Immunobullous Disease Antibody Panel (3001409).
For more information about components, methodology, and specimen type, see the ARUP Immunobullous Disease Testing Comparison tool.
New York DOH Approval Status
Specimen Required
Plain red or serum separator tube.
Transfer 2 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)
Refrigerated/Ambient
Hemolyzed or lipemic specimens. Plasma.
As a general rule, serum specimens should be shipped to the laboratory as soon as possible.
Store refrigerated unless shipping promptly (within 2 hours). Transport at ambient temperature to arrive within 7 days. If 7-14 days until received in laboratory, store and ship refrigerated. If greater than 14 days, serum specimens must be stored and shipped frozen.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Indefinitely
Methodology
Semi-Quantitative Indirect Immunofluorescence (IIF)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)
Performed
Varies
Reported
3-9 days
Reference Interval
By report
Interpretive Data
Refer to report.
Performed by non-ARUP Laboratory
Note
For specimens less than 0.5 mL, call the Immunodermatology Laboratory at 801-581-7139.
Hotline History
Hotline History
CPT Codes
88346; 88350 x3; 83516 x2
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0092002 | Pemphigoid Antibody Panel | 48767-8 |
| 2010914 | EER Pemphigoid Antibody Panel | 11526-1 |
Aliases
- atypical epithelial antibody-associated disease
- basement membrane zone antibody-associated disease
- Brunsting-Perry cicatricial pemphigoid
- Brunsting-Perry pemphigoid
- bullous lupus erythematosus
- Bullous Pemphigoid
- bullous pemphigoid antigen 1 or BPAg1
- bullous pemphigoid antigen 2 or BPAg2, NC16A
- bullous systemic lupus erythematosus
- childhood immunobullous disease
- chronic bullous disease of childhood
- cicatricial pemphigoid
- collagen type 17
- collagen type XVII
- dermal basement membrane zone (floor) antibodies with split skin substrate
- epidermal basement membrane zone (roof) antibodies with split skin substrate
- epidermolysis bullosa acquisita (EBA)
- epithelial antibody-associated disease
- hemidesmosomal protein antibodies
- hemidesmosome antibodies
- IgA mucous membrane pemphigoid
- IgA variant epidermolysis bullosa acquisita (EBA)
- IgG/IgA basement membrane zone antibodies
- immunobullous disease of childhood
- indirect fluorescence assay
- indirect fluorescent antibody (IFA)
- indirect immunofluorescent assay
- linear IgA bullous dermatosis
- linear IgA disease
- linear IgA/IgG bullous dermatosis
- mixed epithelial antibody-associated disease
- mixed immunobullous disease of childhood
- mucous membrane pemphigoid
- ocular cicatricial pemphigoid
- Pemphigoid Antibody Panel - Epithelial Basement Membrane Zone Antibodies, lgG and lgA, BP180 and BP2
- pemphigoid variants
- salt-split skin floor antibodies
- salt-split skin roof antibodies
- salt-split skin test
- subepithelial immunobullous disease
- type XVII collagen
